Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

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Assessing 1-h plasma glucose and shape of the glucose curve during oral glucose tolerance test.

OBJECTIVE To assess the cutoff values at different time points for impaired glucose regulation (IGR) and diabetes, the glucose curve and isolated 1-h hyperglycemia were monitored during an oral glucose tolerance test (OGTT). METHODS Two thousand eight hundred and eighty-six subjects (1300 men and 1586 women) were recruited to have an OGTT. Plasma was collected at 0, 30, 60, 120, and 180 min t...

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Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Introduction Impaired glucose tolerance (IGT) is diagnosed by a standardized oral glucose tolerance test (OGTT). However, the OGTT is laborious, and when not performed, glucose tolerance cannot be determined from fasting samples retrospectively. We tested if glucose tolerance status is reasonably predictable from a combination of demographic, anthropometric, and laboratory data assessed at one ...

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The One-Hour Oral Glucose Tolerance Test

Response of middle-aged men to loo-gram and 50-gram doses of glucose given fasting and 1, 2, and 3 hours after meal. PREFACE This is one of several studies designed to evaluate examination procedures used in the first cycle of the Health ESamination Survey. These studies constitute efforts to define and to measure some of the components of variation in the examination techniques. Where the tech...

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The oral glucose tolerance test, revisited.

Hyperglycaemia is necessary for the diagnosis of diabetes. For more than 35 years there has been a spirited controversy about the diagnostic criteria for Type 2 diabetes, in particular about the oral glucose tolerance test (OGTT). In a 1975 paper Marvin Siperstein referred to the OGTT as ‘a pitfall in the diagnosis of diabetes mellitus’. Now the controversy has returned in the wake of the 1997 ...

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Revision of the oral glucose tolerance test: a pilot study.

Nausea and vomiting have been recurrent problems with the oral glucose tolerance tests (OGTT) used to diagnose diabetes. We believe the nausea is associated with delayed gastric emptying caused by the high osmolarity of the glucose solution. In our pilot study, both the "standard" 100-g glucose OGTT and our new modified (lower osmolar) glucose solution were evaluated. Considerably delayed gastr...

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ژورنال

عنوان ژورنال: Diabetes Research and Clinical Practice

سال: 2011

ISSN: 0168-8227

DOI: 10.1016/j.diabres.2011.05.035